Acute Agitation: Comparing New Medications

We are studying how well sublingual dexmedetomidine and buccal midazolam work for calming patients in emergency settings compared to oral lorazepam. We also want to know about their safety and how satisfied patients feel with these treatments.

>2 years Efficacy phase (II)Confirmation phase (III)No Placebo Investigational Medicines OralPsychiatry

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Lorazepam Orion

Lorazepam Orion is a medicine used to relieve anxiety and to help with short-term sleep problems.

Midazolam Medical Valley

Midazolam Medical Valley is a sedative used to help people relax or sleep during medical procedures and to treat seizures.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dexmedetomidine

Dexmedetomidine is a sedative substance used to calm patients and reduce anxiety and pain during surgery or in intensive care.

Lorazepam

Lorazepam is a substance that reduces anxiety and produces calming, sedative effects to ease panic, severe agitation, or help with sleep.

Midazolam

Midazolam is a substance that produces sedation and reduces anxiety, often used to calm patients before procedures or help control seizures.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Igalmi

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Akivass

Ansilor

Anxiar

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Psykiatrisk Center Kobenhavn

Psykiatrisk Center København

Frederiksberg, Denmark

Sponsor: Psykiatrisk Center Kobenhavn

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.