Acute Brain Injury: Apomorphine and Psilocybin Study

We are exploring the safety of two medications in patients who are unresponsive in the ICU due to brain injury. The goal is to find effective doses while monitoring for any side effects.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Apomorfin Pharmswed
Apomorfin Pharmswed is a medicine used to quickly relieve sudden return of Parkinson’s symptoms when regular treatment wears off.
Natriumchlorid Fresenius Kabi
Natriumchlorid Fresenius Kabi is a sterile salt solution used to replace body fluids and to dilute or deliver medicines into a vein.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Apomorphine Hydrochloride Hemihydrate
Apomorphine hydrochloride hemihydrate is a substance that rapidly restores movement during sudden 'off' episodes in Parkinson's disease.
Extraction Solvent: Methanol
Sodium Chloride
Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Psilocybin
Psilocybe Cubensis

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Addex Natriumklorid
Aminoplasmal E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Rigshospitalet
Dept. of Neurology (sect 7076), Rigshospitalet-Blegdamsvej, Copenhagen University Hospital
Copenhagen, Denmark
Bispebjerg Hospital
Dept. of Anaesthesia and Intensive Care, Bispebjerg Hospital, Copenhagen University Hospital
Frederiksberg, Denmark
Rigshospitalet
Dept. of Neuroanaestelogy, Rigshospitalet-Glostrup, Copenhagen University Hospital
Glostrup, Denmark
Sponsor: Rigshospitalet
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.