Acute Demyelinating Syndromes in Children: Azathioprine vs. Rituximab

We are studying whether starting treatment immediately with azathioprine or rituximab helps children with anti-MOG antibodies better than delaying treatment until a second attack. The goal is to see which method reduces relapses and improves health outcomes.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Prednisolone Eg
Prednisolone Eg is a steroid medicine used to reduce swelling and treat allergies, asthma attacks, and certain immune system conditions.
Prednisone Eg
Prednisone Eg is a steroid medicine that reduces inflammation and treats allergic, autoimmune, and other inflammatory conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Azathioprine
Azathioprine is a substance that suppresses the immune system to prevent organ rejection and treat autoimmune diseases.
Methylprednisolone
Methylprednisolone is a corticosteroid that reduces inflammation and calms an overactive immune system.
Prednisolone
Prednisolone is a steroid substance that reduces inflammation and suppresses an overactive immune response.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adelcort®
Alpicort
Alpicort E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire De Toulouse
Pediatrics - Neurology and infectiologyinfectiology
Blagnac, France
Centre Hospitalier Universitaire De Bordeaux
pediatric neurologist
Bordeaux, France
Hospices Civils De Lyon
Paediatrics neurology
Bron, France

Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.