Acute Myeloid Leukemia: Cobicistat with Venetoclax and Azacitidine

We are studying a new treatment combination for patients with acute myeloid leukemia who cannot receive intensive chemotherapy. This trial aims to see if adding cobicistat to venetoclax and azacitidine improves survival and treatment outcomes.

3-6 monthsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOralInjectionInternal MedicineOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Azacitidine
Cobaxid
Venclyxto
Venclyxto is a medicine used to treat certain types of blood cancer, including some forms of leukemia and lymphoma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Azacitidine
Azacitidine is a substance that treats certain bone marrow disorders and blood cancers by slowing abnormal blood cell growth and restoring healthier blood production.
Cobamamide
Cobamamide is an active form of vitamin B12 used to correct B12 deficiency and support nerve function.
Cobicistat
Cobicistat is a substance that boosts levels of certain HIV treatments by slowing their breakdown in the body.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Azacitdine Clonmel
Azacitidin
Azacitidin Aliud

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
Jeroen Bosch Ziekenhuis Stichting
Hematology
's-Hertogenbosch, Netherlands
Amsterdam UMC
Hematology
Amstelveen, Netherlands
Stichting OLVG
Hematology
Amsterdam, Netherlands
Sponsor: Haemato Oncology Foundation For Adults Netherlands
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.