Acute Myeloid Leukemia: Comparing Conditioning Regimens in Children

We are studying two different treatment plans for children with Acute Myeloid Leukemia undergoing stem cell transplants. Our goal is to find out which plan leads to better survival and fewer side effects.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Busulfan Fresenius Kabi
Busulfan Fresenius Kabi is a chemotherapy medicine used to destroy bone marrow cells before a stem cell transplant and to treat some blood cancers.
Evoltra
Grafalon
Grafalon is a medicine that weakens the immune system to help prevent and treat rejection after organ transplants.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anti-T Lymphocyte Immunoglobulin For Human Use
Anti-T lymphocyte immunoglobulin is a preparation of antibodies that reduces activity of immune T cells to prevent or treat organ transplant rejection.
Busulfan
Busulfan is a substance used to destroy bone marrow cells before a bone marrow transplant and to treat certain blood cancers.
Clofarabine
Clofarabine is a chemotherapy substance used to treat certain types of leukemia by targeting and killing rapidly dividing cancer cells.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Alkeran

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bussulfano Accord
Busulfan Accord
Busulfan Aspen Pharma

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven
Pediatric hemato-oncology
Heverlee, Belgium
Association Hospitaliere De Bruxelles Hopital Universitaire Des Enfants Reine Fabiola
Pediatric hemato-oncology
Jette, Belgium
Universitair Ziekenhuis Gent
Pediatric Hemato-oncology and stem cell transplantation
Ledeberg, Belgium

Sponsor: Vaestra Goetalandsregionen
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.