Acute Myeloid Leukemia: Hydroxyurea and Valproic Acid Study

We are investigating a new treatment combination for patients with acute myeloid leukemia or high-risk myelodysplastic syndrome who cannot receive standard chemotherapy. The study will assess safety, effectiveness, and quality of life.

6-12 monthsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesOralHematologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Hydroxycarbamide
Hydroxycarbamide is a substance used to treat certain blood cancers and reduce painful crises in sickle cell disease.
Mercaptopurine
Mercaptopurine is an anticancer substance used to slow the growth of cancer cells, commonly for treating certain types of leukemia.
Sodium Valproate
Sodium valproate is a substance that helps control seizures and stabilize mood in conditions like epilepsy and bipolar disorder.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Helse Bergen HF
Department of Medicine, Haukeland University Hospital
Bergen, Norway
Helse Forde HF
Department of Oncology
Førde, Norway
Oslo University Hospital HF
Department of Hematology
Oslo, Norway
Sponsor: Helse Bergen HF
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.