Acute Myeloid Leukemia: Ivosidenib, Azacitidine, and Venetoclax Study

We are investigating whether adding venetoclax to ivosidenib and azacitidine helps patients with newly diagnosed IDH1-mutated AML who cannot undergo intensive chemotherapy. The goal is to see if this combination improves survival and remission rates.

>2 years Confirmation phase (III)Post-Trial Drug Access Investigational Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Azacitidine

Venclyxto

Venclyxto is a medicine used to treat certain types of blood cancer, including some forms of leukemia and lymphoma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Azacitidine

Azacitidine is a substance that treats certain bone marrow disorders and blood cancers by slowing abnormal blood cell growth and restoring healthier blood production.

Ivosidenib

Ivosidenib is a cancer-targeting substance used to treat cancers that have an IDH1 gene mutation, especially acute myeloid leukemia.

Venetoclax

Venetoclax is a substance used to treat certain blood cancers by helping cancer cells die.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Venetoclax

Ag-120/S95031

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Azacitdine Clonmel

Azacitidin

Azacitidin Aliud

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Vorarlberger Krankenhaus-Betriebsgesellschaft mbH

Internal Medicine

Feldkirch, Austria

SCRI CCCIT Ges.m.b.H.

Medical Department with Hematology, Medical oncology, Hemostageology, infectious Diseas

Salzburg, Austria

Hanusch Krankenhaus Der Wiener Gebietskrankenkasse

Medical Department

Vienna, Austria

Sponsor: Hemato-Oncologie voor Volwassenen Nederland (Hovon) Stichting

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.