Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia (AML) is a type of cancer that affects the blood and bone marrow, characterized by the rapid growth of abnormal white blood cells that interfere with normal blood cell production.
Acute Myeloid Leukemia: Molidustat and Ivosidenib Combination
We are investigating whether the combination of molidustat and ivosidenib can effectively treat patients with IDH1-mutated acute myeloid leukemia or myelodysplastic syndrome. This study aims to assess how well this treatment works and its safety.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Myelodysplastic Syndrome (MDS)
Myelodysplastic Syndrome (MDS) is a group of disorders caused by poorly formed or dysfunctional blood cells, leading to ineffective blood cell production and a risk of progression to leukemia.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you at least 18 years old?
- Do you have a diagnosis of relapsed or refractory acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS)?
- Are you currently pregnant or breastfeeding?
- Are you taking any medications that are known to interact with investigational drugs, such as blood thinners or certain cancer treatments?
- Do you have any significant heart problems, such as heart failure or a recent heart attack?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Musredo
Molidustat
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Charite Universitaetsmedizin Berlin KöR
Campus Virchow Klinikum Medizinische klinik m.S. hämatologie, Onkologie und Tumorimmunlogie
Berlin, Germany
Staedtisches Klinikum Braunschweig gGmbH
Medizinische Klinik III
Braunschweig, Germany
Gesundheit Nord gGmbH Klinikverbund Bremen
Innere Medizin I
Bremen, Germany
Sponsor: Medizinische Hochschule Hannover
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.