Acute Myeloid Leukemia: Venetoclax and Azacitidine Study

We are comparing a new treatment combination with standard chemotherapy for patients with newly diagnosed acute myeloid leukemia and NPM1 mutations. The goal is to see if this new approach is more effective and easier to tolerate.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Azacitidine
Cytarabine
Mitoxantrone Sandoz
Mitoxantrone Sandoz is a chemotherapy medicine used to treat certain cancers and some types of multiple sclerosis.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Azacitidine
Azacitidine is a substance that treats certain bone marrow disorders and blood cancers by slowing abnormal blood cell growth and restoring healthier blood production.
Cytarabine
Cytarabine is a chemotherapy substance used to treat certain blood cancers, especially acute leukemias.
Daunorubicin Hydrochloride
Daunorubicin hydrochloride is a cancer-fighting substance used to treat certain blood cancers like leukemia by killing rapidly dividing cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alexan
Ara-Cell
Aracytin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Sozialstiftung Bamberg
Medizinische Klinik V; Hämatologie und Internistische Onkologie
Bamberg, Germany
Klinikum Bielefeld gGmbH
Klinik für Hämatologie, Onkologie, Palliativmedizin und Stammzelltherapie
Bielefeld, Germany
Klinikum Chemnitz gGmbH
Klinik für Innere Medizin III
Chemnitz, Germany

Sponsor: Technische Universitaet Dresden
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.