Acute Myeloid Leukemia: Vyxeos and Clofarabine Study

We are testing a new combination treatment for children with relapsed or refractory AML to find the best dose and evaluate its safety. The study aims to see if this treatment can help achieve remission and support future stem cell transplants.

Safety phase (I)No Placebo Standard Medicines InjectionOncologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Evoltra

Vyxeos Liposomal

Vyxeos Liposomal is a chemotherapy medicine used to treat certain types of acute myeloid leukemia.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Clofarabine

Clofarabine is a chemotherapy substance used to treat certain types of leukemia by targeting and killing rapidly dividing cancer cells.

Cytarabine

Cytarabine is a chemotherapy substance used to treat certain blood cancers, especially acute leukemias.

Daunorubicin

Daunorubicin is a substance used to treat certain types of cancer, especially leukemias, by killing rapidly dividing cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Clofarabin Koanaa

Clofarabin Ratiopharm

Clofarabin Teva

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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St. Anna Kinderspital GmbH

Division of Haematology and Oncology

Vienna, Austria

Rigshospitalet

Pediatrics

Copenhagen, Denmark

Charite Universitaetsmedizin Berlin KöR

Pediatrics

Berlin, Germany

Sponsor: Prinses Maxima Centrum voor Kinderoncologie B.V.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.