Acute Pulmonary Embolism: Reduced Dose Thrombolytic Treatment

We are studying whether a lower dose of thrombolytic therapy is effective and safe for patients with intermediate high-risk acute pulmonary embolism. This research aims to improve treatment outcomes and reduce health risks.

>2 years ≤5 visits Confirmation phase (III)Investigational Medicines InjectionCardiologyInternal MedicinePulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Actilyse 50

Actilyse 50 is a medicine used in emergencies to dissolve blood clots that cause strokes, heart attacks, or serious lung clots.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Alteplase

Alteplase is a substance that dissolves blood clots to restore blood flow in emergencies like stroke, heart attack, or pulmonary embolism.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Actilyse

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Actilyse

Actilyse 10

Actilyse 20

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Ordensklinikum Linz GmbH

2nd Internal Department - Cardiology, Angiology & Internal Intensive Care Medicine

Linz, Austria

Ordensklinikum Linz GmbH

Internal Medicine II

Linz, Austria

Centre Hospitalier Universitaire D'Angers

Urgences adultes

Angers, France

Sponsor: Assistance Publique Hopitaux De Paris

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.