Acyclovir for ICU Patients with Herpes Simplex Virus Reactivation

We are studying whether acyclovir can help reduce mortality and improve recovery in intubated patients with Herpes simplex virus reactivation. This trial compares acyclovir to a placebo to see which treatment is more effective.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Aciclovir
Aciclovir is an antiviral medicine used to treat herpes infections such as cold sores, genital herpes, and shingles.
Aciclovir Viatris
Aciclovir Viatris is an antiviral medicine used to treat herpes infections like cold sores, chickenpox, and shingles.
Chlorure De Sodium B. Braun
Chlorure De Sodium B. Braun is a sterile saline solution used to hydrate patients, replace fluids, and clean wounds or medical equipment.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Aciclovir
Aciclovir is a substance that fights viral infections caused by herpes viruses, helping treat cold sores, genital herpes, and shingles.
Sodium Chloride
Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.
Sodium Chloride Solution 0.9%
Sodium chloride 0.9% is a sterile salt solution used to replace fluids and electrolytes, hydrate patients, and clean wounds or body cavities.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acevirex
Acevirex
Acic

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier De Versailles
medical-surgical intensive care
Le Chesnay, France
Assistance Publique Hopitaux De Paris
Surgical Intensive Care Unit
Salpêtrière, France
Assistance Publique Hopitaux De Paris
Anesthesia and Intensive Care Department
Salpêtrière, France

Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.