ADPKD Treatment: Metformin vs. Tolvaptan

We are studying whether Metformin can effectively slow kidney function decline in adults with Autosomal Dominant Polycystic Kidney Disease compared to Tolvaptan. The trial also examines the safety and impact on kidney size and symptoms.

>2 years 16-20 visits Confirmation phase (III)No Placebo Standard Medicines OralInternal MedicineNephrology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Jinarc

Jinarc is a medicine used to slow the progression of polycystic kidney disease, a hereditary condition that causes many fluid-filled cysts in the kidneys.

Tolvaptan

Tolvaptan is a medicine that helps the body get rid of excess water to treat low blood sodium and certain kidney conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Metformin

Metformin is a substance that helps lower blood sugar in people with type 2 diabetes.

Tolvaptan

Tolvaptan is a substance that raises low blood sodium and can slow kidney function decline in people with certain polycystic kidney disease.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Gurdatol

Samsca

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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University Hospital Consorziale Policlinico

U.O. di Nefrologia Dialisi e Trapianti

Bari, Italy

IRCCS Azienda Ospedaliero Universitaria di Bologna - Policlinico S. Orsola-Malpighi

U.O. Nefrologia, Dialisi e Trapianto

Bologna, Italy

ASST Spedali Civili di Brescia

U.O. Nefrologia

Brescia, Italy

Sponsor: University Of Bari Aldo Moro

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.