Adrenocortical Carcinoma: Mitotane Treatment Study

We are comparing standard mitotane therapy to mitotane combined with chemotherapy for patients at high risk of cancer recurrence after surgery. This study aims to find out which treatment helps patients live longer and maintain a better quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Etoposide
Etoposide is a chemotherapy medicine used to treat various types of cancer.
Filgrastim Hexal
Filgrastim Hexal is a medicine that boosts white blood cell production to help reduce infection risk during chemotherapy or after bone marrow transplant.
Ondansetron
Ondansetron is a medicine that helps prevent nausea and vomiting after surgery or during cancer treatment.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cisplatin
Cisplatin is a substance used in chemotherapy to kill or stop the growth of cancer cells.
Etoposide
Etoposide is a substance used to treat certain cancers by stopping fast-growing cancer cells from dividing.
Filgrastim
Filgrastim is a substance that stimulates production of neutrophils, a type of white blood cell, to help prevent infections in people with low counts.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Accofil
Atossa
Avessaron

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut De Cancerologie De L Ouest
Oncologie médicale
Angers, France
Hospices Civils De Lyon
Endocrinologie, de diabétologie et des maladies métaboliques A
Bron, France
Centre Hospitalier Universitaire De Bordeaux
Endocrinologie – Oncologie endocrinienne
Canéjan, France

Sponsor: Uppsala University Hospital
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.