Advanced Breast Cancer: Capivasertib with CDK4/6 Inhibitors

We are studying a new treatment combining capivasertib with CDK4/6 inhibitors and fulvestrant for patients with advanced hormone receptor-positive, HER2-negative breast cancer. The goal is to see if this combination improves treatment outcomes compared to standard therapies.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Faslodex
Faslodex is a medicine used to treat advanced breast cancer by blocking hormones that help the cancer grow.
Ibrance
Ibrance is a cancer medicine used with hormone therapy to treat certain types of advanced or spread breast cancer.
Kisqali
Kisqali is a medicine used to treat certain types of advanced or metastatic breast cancer by slowing cancer cell growth.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Abemaciclib
Abemaciclib is a substance that slows growth of certain breast cancer cells by blocking proteins that help them divide.
Capivasertib
Capivasertib is a substance that blocks a protein that helps cancer cells grow to help slow certain cancers.
Fulvestrant
Fulvestrant blocks and destroys estrogen receptors to treat hormone receptor–positive breast cancer.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Afultrant
Ambiful
Falvax

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Algemeen Ziekenhuis Klina
Oncology-Hematology
Brasschaat, Belgium
Pole Hospitalier Jolimont
Medical Oncology
Fayt-lez-Manage, Belgium
UZ Leuven
Gynaecology department
Heverlee, Belgium

Sponsor: AstraZeneca AB
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.