Advanced Breast Cancer: Elacestrant and Everolimus Study

We are studying a combination of elacestrant and everolimus for patients with advanced breast cancer that has specific mutations. The goal is to see if this treatment helps delay cancer progression compared to a placebo.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Everolimus Ratiopharm
Everolimus Ratiopharm is a medicine used to treat certain types of cancer and to help prevent organ transplant rejection.
Goserelin Endomedica
Goserelin Endomedica is a medicine that lowers sex hormone levels to treat prostate cancer and some women's reproductive conditions like endometriosis.
Leuprorelin Sandoz
Leuprorelin Sandoz is a hormone-suppressing medicine used to treat prostate cancer, endometriosis, uterine fibroids, and early puberty.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Betamethasone Sodium Phosphate
Betamethasone sodium phosphate is a corticosteroid substance that reduces inflammation and suppresses immune reactions in allergic, inflammatory, and skin conditions.
Dexamethasone
Dexamethasone is a steroid that reduces inflammation and suppresses the immune system to treat allergic, inflammatory, and autoimmune conditions.
Elacestrant
Elacestrant is a substance that blocks and reduces estrogen receptor activity to treat estrogen receptor–positive breast cancer.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Placebo

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aderolio
Aderolio 250 Mcg Tablets
Aderolio 500 Mcg Tablets

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medizinische Universitaet Innsbruck
Department of Gynecology and Obsterics
Innsbruck, Austria
Ordensklinikum Linz GmbH
Internal Medicine I: Medical Oncology and Hematology
Linz, Austria
Priv. Doz. Dr. Michael Hubalek
Gynecology + Breast Center
Schwaz, Austria

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.