Advanced Breast Cancer: PF-07220060 with Letrozole

We are studying a new medicine, PF-07220060, combined with letrozole for adults with HR-positive, HER2-negative advanced breast cancer. This trial compares its effectiveness to standard treatments in patients who haven't had prior systemic therapy.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Ibrance
Ibrance is a cancer medicine used with hormone therapy to treat certain types of advanced or spread breast cancer.
Letrozole
Letrozole is a medicine used to treat certain breast cancers in women after menopause by lowering hormones that can fuel tumor growth.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Abemaciclib
Abemaciclib is a substance that slows growth of certain breast cancer cells by blocking proteins that help them divide.
Letrozole
Letrozole is a substance that lowers estrogen to treat certain types of breast cancer in postmenopausal women.
Palbociclib
Palbociclib is a substance that slows growth of certain breast cancer cells by blocking proteins that control cell division in advanced disease.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Pf-07220060

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aletro
Allenda
Aromek

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Onze-Lieve-Vrouwziekenhuis
Oncology
Aalst, Belgium
Az Maria Middelares Gent
Oncology
Gent, Belgium
Grand Hopital De Charleroi
Oncology & Hematology
Gilly, Belgium

Sponsor: Pfizer Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.