Advanced Breast Cancer: Saruparib and Camizestrant Study

We are studying a new combination treatment for adults with advanced hormone receptor-positive, HER2-negative breast cancer. The goal is to see if it helps patients live longer without disease progression compared to standard therapies.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Anastrozole
Anastrozole is a medicine used to treat certain breast cancers by reducing estrogen levels to help stop tumor growth.
Exemestane
Exemestane is a medicine used to lower estrogen and treat certain breast cancers in women who have gone through menopause.
Fulvestrant Eg
Fulvestrant Eg is a medicine used to treat advanced or metastatic breast cancer that depends on hormones.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Abemaciclib
Abemaciclib is a substance that slows growth of certain breast cancer cells by blocking proteins that help them divide.
Anastrozole
Anastrozole is a substance that lowers estrogen levels to help treat and prevent hormone-sensitive breast cancer in postmenopausal women.
Exemestane
Exemestane is a substance that lowers estrogen levels to help treat hormone-sensitive breast cancer in postmenopausal women.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Saruparib
Camizestrant

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adiunastrol
Afultrant
Agerdex

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz
Clinical Division for Oncology
Graz, Austria
Ordensklinikum Linz GmbH
Interne I: Medizinische Onkologie und Haematologie
Linz, Austria
Medical University Of Vienna
Universitätsklinik f. Innere Medizin I
Vienna, Austria

Sponsor: AstraZeneca AB
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.