Advanced Breast Cancer: Trastuzumab Deruxtecan vs. CDK4/6 Inhibitors

We are studying whether trastuzumab deruxtecan is more effective than a combination of CDK4/6 inhibitors and endocrine therapy for patients with HR-positive, HER2-low advanced breast cancer. This research aims to improve treatment options for this specific group of patients.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Anastrozol Teva
Anastrozol Teva is a medicine used to treat certain breast cancers in postmenopausal women by lowering estrogen that helps tumors grow.
Exemestano Teva
Exemestano Teva is a medicine used to treat certain breast cancers in postmenopausal women by lowering estrogen levels.
Fulvestrant Teva
Fulvestrant Teva is a medicine used to treat hormone-driven advanced breast cancer by blocking estrogen's effects that help tumors grow.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Abemaciclib
Abemaciclib is a substance that slows growth of certain breast cancer cells by blocking proteins that help them divide.
Anastrozole
Anastrozole is a substance that lowers estrogen levels to help treat and prevent hormone-sensitive breast cancer in postmenopausal women.
Exemestane
Exemestane is a substance that lowers estrogen levels to help treat hormone-sensitive breast cancer in postmenopausal women.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ds-8201a

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adiunastrol
Afultrant
Agerdex

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz
Internal Medicine
Graz, Austria
Johannes Kepler University Linz
Hematology and Oncology
Linz, Austria
Medical University Of Vienna
Department of Medicine I, Division of Oncology
Vienna, Austria

Sponsor: Medica Scientia Innovation Research S.L.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.