Advanced Cancer: Targeted Therapy Study

We are evaluating new treatments that specifically target the molecular changes in tumors of patients with advanced or metastatic cancer. The goal is to see how well these therapies work and their safety profile.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cabozantinib Ipsen
Cabozantinib Ipsen is a cancer medicine used to treat certain advanced kidney, liver, and thyroid cancers.
Zelboraf
Zelboraf is a medicine used to treat melanoma (a type of skin cancer) that has spread and has a specific gene change.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Alectinib Hydrochloride
Alectinib hydrochloride is a substance that targets lung cancers with an ALK gene change to slow tumor growth and spread.
Avapritinib
Avapritinib is a substance used to treat certain rare tumors of the digestive tract (gastrointestinal stromal tumors) and advanced systemic mastocytosis.
Cabozantinib
Cabozantinib is a substance used to treat certain advanced cancers by blocking signals that help tumors grow and spread.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Hdm201
Siremadlin

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Cabometyx
Cometriq

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut Bergonie
Oncology
Bordeaux, France
Centre Francois Baclesse
Medical oncology
Caen, France
Institut De Cancerologie Strasbourg Europe
Oncology
Eckbolsheim, France

Sponsor: Centre Leon Berard
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.