Advanced-Stage Cancer with BRAF Mutation
Advanced-stage cancer with BRAF mutation refers to cancers that have spread beyond their original site and have a specific genetic change in the BRAF gene, which can affect treatment options and outcomes.
Advanced Cancers with BRAF Mutations: Sorafenib and Trametinib Study
We are testing a combination of two medications for patients with advanced-stage cancers that have BRAF mutations. The goal is to find the best dose and understand how well this treatment works and its safety.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you at least 18 years old?
- Do you have metastatic cancer (cancer that has spread to other parts of the body)?
- Are you currently pregnant or breastfeeding?
- Are you taking any medications that are strong blood thinners, like Warfarin, Eliquis, or Xarelto?
- Have you had major surgery or radiation therapy in the past 4 weeks?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Mekinist
What similar medicines might you know?
Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.
Fenesa
Fenesa
Renixola
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
Loading map...
Technische Universitaet Dresden
Nationales Centrum für Tumorerkrankungen (NCT)
Dresden, Germany
Medical Center - University Of Freiburg
Hematology/Oncology
Freiburg, Germany
Universitaetsklinikum Heidelberg AöR
Department of Internal Medicine V and IV
Heidelberg, Germany
Sponsor: Medical Center - University Of Freiburg
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.