Advanced Colorectal Cancer: Cetuximab with Encorafenib and Binimetinib

We are studying a combination of three medications for patients with BRAF V600E mutated advanced colorectal cancer. The goal is to see if this treatment can help make surgery possible and improve overall health outcomes.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Braftovi
Braftovi is a cancer medicine used to treat certain advanced melanomas and some colorectal cancers that have a specific genetic mutation.
Erbitux
Erbitux is a cancer treatment used to help slow the growth of certain colorectal and head and neck cancers.
Mektovi
Mektovi is a medicine used to treat advanced melanoma, a type of skin cancer, in patients whose tumors have specific genetic changes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Binimetinib
Binimetinib is a targeted cancer treatment that blocks a protein pathway to slow growth of certain tumors, including some melanomas.
Cetuximab
Cetuximab is a substance that targets a protein on cancer cells to help slow or stop growth in colorectal and head and neck cancers.
Encorafenib
Encorafenib is a substance that targets cancer cells with a specific BRAF gene mutation to help slow tumor growth.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Cotellic

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Complexo Hospitalario Universitario A Coruna
Oncology
A Coruña, Spain
Hospital Universitario De Navarra
Oncology
Barañáin, Spain
Hospital Universitari Vall D Hebron
Oncology
Barcelona, Spain

Sponsor: Asociacion Grupo Tratamiento De Tumores Digestivos
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.