Advanced GEP-NET: [177Lu]Lu-DOTA-TATE Treatment Study

We are testing a new treatment combining [177Lu]Lu-DOTA-TATE and octreotide LAR for patients with advanced Grade 1 and Grade 2 GEP-NET. The goal is to see if it can better delay disease progression and improve quality of life compared to existing therapies.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Lutathera
Lutathera is a targeted radiation medicine used to treat certain neuroendocrine tumors that start in the digestive system or pancreas.
Octreotide
Octreotide is a medicine that reduces excess hormone effects, used for conditions like acromegaly and certain hormone-secreting tumors.
Sandostatin Lar
Sandostatin LAR is a long-acting injection used to control hormone-related symptoms and excess growth hormone from certain tumors.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Arginine Hydrochloride
Arginine hydrochloride is a form of the amino acid arginine used to raise arginine levels and support blood flow and wound healing.
Citric Acid
Citric acid is used to adjust acidity, help preserve products, and add a tart flavor in pharmaceutical and food formulations.
Dimeticone
Dimeticone is a silicone-based substance used to protect and soothe skin and to help remove head lice by coating them.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Lysakare

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Octrayne
Octrayne
Octreo

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire De Bordeaux
1401: Endocrinology and Endocrine Oncology
Bordeaux, France
Hospices Civils De Lyon
1404: Medical Oncology
Bron, France
Centre Hospitalier Universitaire De Bordeaux
1401: Endocrinology and Endocrine Oncology
Canéjan, France

Sponsor: Novartis Pharma AG
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.