Advanced Melanoma: Lifileucel with Pembrolizumab

We are investigating whether a new treatment combining lifileucel with pembrolizumab is more effective than pembrolizumab alone for patients with untreated, advanced melanoma. The study aims to assess both effectiveness and safety.

Confirmation phase (III)Post-Trial Drug Access No Placebo Cost Reimbursement Investigational Medicines Oral InjectionDermatologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cyclophosphamide Sandoz

Cyclophosphamide Sandoz is a chemotherapy medicine used to treat various cancers and some severe autoimmune conditions by suppressing the immune system.

Endoxan

Endoxan is a chemotherapy medicine used to treat various types of cancer and some severe autoimmune conditions.

Endoxan Lyophilisat

Endoxan Lyophilisat is a medicine used to treat many kinds of cancer and some serious autoimmune diseases.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Aldesleukin

Aldesleukin is a synthetic form of a natural immune-signaling protein that boosts the body's immune response to help treat certain cancers.

Cyclophosphamide

Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.

Cyclophosphamide Monohydrate

Cyclophosphamide monohydrate is an anti-cancer substance used to treat various cancers and some serious autoimmune diseases.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Lifileucel

Fludarabine Phosphate

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bendarabin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...

UZ Brussel

Oncology

Ganshoren, Belgium

Cliniques Universitaires Saint-Luc

Oncology

Sint-Stevens-Woluwe, Belgium

CHU De Liege

Oncology

Tilff, Belgium

Sponsor: Iovance Biotherapeutics Inc.

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.