Advanced Melanoma: Tebentafusp Treatment Study

We are studying a new treatment for advanced melanoma in patients who have already been treated. This trial compares tebentafusp alone and with pembrolizumab against standard treatment options to see if it improves survival and quality of life.

Efficacy phase (II)Confirmation phase (III)Post-Trial Drug Access No Placebo Cost Reimbursement Standard Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Keytruda

Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.

Kimmtrak

Kimmtrak is a medicine used to treat uveal melanoma, a rare form of eye cancer that has spread.

Paracetamol

Paracetamol relieves pain and reduces fever for conditions like headaches, muscle aches, and colds.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dexamethasone

Dexamethasone is a steroid that reduces inflammation and suppresses the immune system to treat allergic, inflammatory, and autoimmune conditions.

Dexamethasone Phosphate

Dexamethasone phosphate is a corticosteroid substance that reduces inflammation and suppresses immune system activity.

Diphenhydramine Hydrochloride

Diphenhydramine hydrochloride is a substance that relieves allergy symptoms like sneezing, itching, and runny nose and often causes drowsiness.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

4-In-One Flu Relief

6 Years Plus Paracetamol Boots

Abacat

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz

Universitätsklinik für Dermatologie und Venerologie

Graz, Austria

Johannes Kepler University

Universitätsklinik für Dermatologie und Venerologie

Linz, Austria

SCRI CCCIT Ges.m.b.H.

Universitätsklinik für Innere Medizin III der PMU

Salzburg, Austria

Sponsor: Immunocore Limited

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.