Advanced Melanoma: Vusolimogene Oderparepvec with Nivolumab

We are comparing a new treatment combination for advanced melanoma that has worsened after other therapies. The goal is to see if this combination improves survival and response compared to standard treatment options.

Confirmation phase (III)No PlaceboInvestigational MedicinesOralInjectionDermatologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Dacarbazine Medac
Dacarbazine Medac is a chemotherapy medicine used to treat certain types of cancer, including melanoma and Hodgkin lymphoma.
Keytruda
Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.
Opdivo
Opdivo is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dacarbazine
Dacarbazine is a chemotherapy substance used to treat certain cancers, including melanoma and Hodgkin lymphoma.
Dacarbazine Citrate
Dacarbazine citrate is an anticancer substance used to treat certain cancers, including melanoma and Hodgkin lymphoma.
Nivolumab
Nivolumab is a substance that helps the immune system recognize and attack certain cancers.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Vusolimogene
Opdualag
Paclitaxel

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Advecit
Blastomat
Dacarbazin Lipomed

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire De Bordeaux
Dermatology
Bordeaux, France
Centre Hospitalier Universitaire De Lille
Dermatology
La Madeleine, France
Centre Hospitalier Regional De Marseille
Dermatology and Skin Cancer Unit
Marseille, France
Sponsor: Replimune Inc.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.