Advanced Non-Clear Cell Kidney Cancer: XL092 + Nivolumab

We are studying a new treatment combination for patients with advanced or metastatic non-clear cell kidney cancer. The goal is to see if it works better and is safer than the standard treatment.

>2 years 6-10 visits Confirmation phase (III)Post-Trial Drug Access No Placebo Investigational Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Opdivo

Opdivo is a cancer medicine that helps the immune system find and fight tumor cells.

Sunitinib Aqvida

Sunitinib Aqvida is a cancer medicine used to treat certain tumors, including advanced kidney and some digestive system cancers.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Nivolumab

Nivolumab is a substance that helps the immune system recognize and attack certain cancers.

Sunitinib

Sunitinib is a cancer-targeting substance that helps block tumor growth and reduce formation of blood vessels feeding certain tumors.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Xl092

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Egotux

Klertis

Lusmose

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Complex Oncological Center Plovdiv EOOD

Department of medical oncology and oncology diseases in gastroenterology

Plovdiv, Bulgaria

Multiprofile Hospital for Active Treatment Sveta Sofia

Department of medical oncology

Sofia, Bulgaria

University Multiprofile Hospital For Active Treatment St. Ivan Rilski EAD

Department of medical oncology

Sofia, Bulgaria

Sponsor: Exelixis Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.