Advanced Non-Small Cell Lung Cancer: Cemiplimab and BNT116 Combination

We are studying how a new cancer vaccine combined with cemiplimab works for adults with advanced non-small cell lung cancer. This trial will help us understand its effectiveness and safety compared to cemiplimab alone.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Esomenar
Libtayo
Libtayo is a cancer medicine that helps the immune system find and fight certain advanced skin and lung cancers.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cemiplimab
Cemiplimab is a substance that helps the immune system find and attack certain cancers by blocking a protein that suppresses immune cells.
Esomeprazole Magnesium Dihydrate
Esomeprazole magnesium dihydrate is a substance that reduces stomach acid to treat heartburn and other acid-related conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Bnt116
Rbl007
Rbl035

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abigerd
Collezoes
Dansiglat

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
Goethe University Frankfurt
Medizinische Klinik 2: Hämatologie/ Onkologie
Frankfurt am Main, Germany
Justus-Liebig-Universitaet Giessen
Medizinische Klinik IV Organonkologie
Gießen, Germany
LungenClinic Grosshansdorf GmbH
Center for Pneumology and Thoracic Surgery
Großhansdorf, Germany

Sponsor: Regeneron Pharmaceuticals Inc.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.