Advanced Non-Small Cell Lung Cancer: OSIBOOST 2 Study

We are testing a modified dosing strategy of osimertinib, with or without a booster drug, for patients with advanced EGFR mutated NSCLC. This study aims to improve treatment cost-effectiveness and reduce side effects while maintaining effectiveness.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Tagrisso
Tagrisso is a cancer medicine used to treat certain non-small cell lung cancers that have specific gene changes.
Tybost
Tybost is a medicine used to boost other HIV drugs' effectiveness by increasing their levels in the body.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cobicistat
Cobicistat is a substance that boosts levels of certain HIV treatments by slowing their breakdown in the body.
Osimertinib
Osimertinib is a targeted cancer treatment that blocks a specific protein to treat certain non-small cell lung cancers caused by gene changes.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Longoncologie
Amstelveen, Netherlands
Zuyderland Medisch Centrum Stichting
Longoncologie
Geleen, Netherlands
Universitair Medisch Centrum Groningen
Longoncologie
Groningen, Netherlands

Sponsor: University Hospital Maastricht
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.