Advanced Rare Cancers: Domvanalimab + Zimberelimab Study

We are investigating the safety and effectiveness of a new combination therapy for patients with advanced rare cancers that have not responded to previous treatments. This trial includes several types of rare cancers, aiming to find better treatment options.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Folinate De Calcium Kalceks
Folinate De Calcium Kalceks is used to protect healthy cells from certain cancer drugs and to treat a type of vitamin B deficiency.
Oxaliplatine Kabi
A chemotherapy medicine used to treat colon, rectal, and certain other cancers.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.
Durvalumab
Durvalumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein tumors use to hide.
Fluorouracil
Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Zimberelimab
Domvanalimab

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bendafolin
Calcium Folinate As Kalceks
Calcium Folinate Fresenius Kabi

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
Institut De Cancerologie De L Ouest
Oncologie médicale
Avignon, France
Hopital Tenon
Oncologie médicale
Bagnolet, France
Institut Bergonie
Oncologie médicale
Bordeaux, France

Sponsor: Hospices Civils De Lyon
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.