Advanced Solid Tumors: MCLA-158 (Petosemtamab) Study

We are testing a new treatment called MCLA-158 for people with advanced solid tumors to see how well it works and how safe it is. This study looks at its effects alone and in combination with other therapies.

Safety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesInjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate helps protect the body from side effects of some chemotherapy drugs and restores folate (vitamin B9) levels.
Irinotecan
Irinotecan is a chemotherapy medicine used to treat certain cancers, especially colorectal cancer.
Keytruda
Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.
Fluorouracil
Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.
Irinotecan
Irinotecan is a chemotherapy substance used to treat certain cancers by blocking cancer cells from dividing and growing.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alimta
Antrex
Armisarte

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Universitair Ziekenhuis Gent
Oncology
Ledeberg, Belgium
Institut Jules Bordet
Oncology
Negenmanneke, Belgium
Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur
Oncology
Saint-Servais, Belgium
Sponsor: Merus N.V.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.