Advanced Solid Tumors: MOST Plus Treatment Study

We are studying a new maintenance treatment for patients with advanced solid tumors to see if it helps keep the disease stable after initial therapy. This trial compares ongoing treatment with stopping the therapy to understand the best approach.

>2 years ≤5 visits Efficacy phase (II)Post-Trial Drug Access No Placebo Standard Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Imfinzi

Imfinzi is a cancer medicine that helps the immune system find and fight tumor cells.

Imjudo

Imjudo is a cancer medicine that helps the immune system find and attack tumor cells.

Lynparza

Lynparza is a cancer medicine used to treat certain ovarian, breast, pancreatic, and prostate cancers, especially those caused by specific gene changes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Durvalumab

Durvalumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein tumors use to hide.

Nilotinib

Nilotinib is a substance that blocks cancer cell growth by targeting specific enzymes and is used to treat chronic myeloid leukemia.

Olaparib

Olaparib is a substance used to treat certain cancers by blocking a DNA-repair protein so cancer cells cannot fix damage and die.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Krufton

Lobynia

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut Bergonie

Medical Oncology

Bordeaux, France

Institut De Cancerologie Strasbourg Europe

Medical oncology

Eckbolsheim, France

Institut Paoli Calmettes

Medical oncology

Marseille, France

Sponsor: Centre Leon Berard

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.