Aggressive Large B-Cell Lymphoma: Golcadomide After CAR T-Cell Therapy

We are studying whether golcadomide can improve outcomes for patients with aggressive large B-cell lymphoma after receiving CAR T-cell therapy. The trial will look at response rates and safety in those at high risk of relapse.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Kymriah
Kymriah is a personalized cell therapy used to treat certain types of blood cancers, including some leukemias and lymphomas.
Yescarta
Yescarta is a cancer treatment that uses a patient’s own immune cells to fight certain types of lymphoma, a blood cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Axicabtagene Ciloleucel
Axicabtagene ciloleucel is a substance that uses specially modified immune cells to target and kill certain B-cell blood cancers.
Lisocabtagene Maraleucel
Lisocabtagene maraleucel is a personalized CAR T-cell therapy that uses a patient's own immune cells engineered to target and kill certain B-cell cancers.
Pomalidomide
Pomalidomide is a substance used to treat certain blood cancers by helping control abnormal plasma cell growth and modulating the immune system.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Golcadomide
Breyanzi

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire Grenoble Alpes
Hematology
Allières-et-Risset, France
Centre Hospitalier Universitaire De Bordeaux
Hematology
Canéjan, France
CHRU De Nancy
Hematology
Carros, France

Sponsor: Lymphoma Academic Research Organisation
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.