Aggressive Multiple Sclerosis: Stem Cell Transplant Study

We are investigating whether stem cell transplantation can prevent disease activity in people with aggressive multiple sclerosis. The study will also monitor safety and other health changes over time.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carmustine
Carmustine is a chemotherapy medicine used to treat certain cancers, including some brain tumors and blood cancers.
Cytarabine
Etoposide
Etoposide is a chemotherapy medicine used to treat various types of cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Alemtuzumab
Alemtuzumab is a lab-made antibody that targets immune cells and treats certain blood cancers and severe relapsing multiple sclerosis.
Anti-T Lymphocyte Immunoglobulin For Human Use
Anti-T lymphocyte immunoglobulin is a preparation of antibodies that reduces activity of immune T cells to prevent or treat organ transplant rejection.
Carmustine
Carmustine is a substance used to treat certain cancers by damaging or stopping growth of cancer cells.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Kesimpta
Rabbit Anti-Human Thymocyte Immunoglobulin

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Accofil
Alexan
Ara-Cell

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliero-Universitaria San Luigi Gonzaga
SCDO Neurologia
Beinasco, Italy
Careggi University Hospital
SOD di Neurologia 1
Florence, Italy
Careggi University Hospital
SOD Neurologia D'urgenza
Florence, Italy

Sponsor: Fondazione Italiana Sclerosi Multipla Ente Del Terzo Settore/et S
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.