Alcohol-Associated Hepatitis: Alpha-1 Antitrypsin Treatment

We are studying whether intravenous Alpha-1 Antitrypsin can reduce inflammation in patients with severe alcohol-associated hepatitis. The trial also looks at its safety and effects on liver health.

3-6 months ≤5 visits Efficacy phase (II)No Placebo Standard Medicines Oral InjectionHepatologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Prednisolon Nycomed

Prednisolon Nycomed is a medicine that reduces inflammation and calms the immune system to treat allergies, asthma, and other inflammatory conditions.

Prolastin

Prolastin is a medicine given to people with an inherited protein deficiency to help protect their lungs from damage.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Human Alpha1-Proteinase Inhibitor

Human Alpha1-Proteinase Inhibitor is a substance that helps protect the lungs from damage in people with alpha-1 antitrypsin deficiency.

Prednisolone

Prednisolone is a steroid substance that reduces inflammation and suppresses an overactive immune response.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adelcort®

Alfalastin

Alpicort

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medizinische Universitaet Innsbruck

University Hospital for Internal Medicine I

Innsbruck, Austria

Sponsor: Medizinische Universitaet Innsbruck

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.