ALK-Positive Advanced Lung Cancer: NVL-655 vs. Alectinib

We are studying a new medication, NVL-655, for patients with advanced ALK-positive lung cancer who haven't been treated before. The goal is to see if it works better and is safer than the current standard treatment, alectinib.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Alecensa
Alecensa is a cancer medicine used to treat certain types of lung cancer caused by specific genetic changes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Alectinib Hydrochloride
Alectinib hydrochloride is a substance that targets lung cancers with an ALK gene change to slow tumor growth and spread.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Nvl-655

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medizinische Universitaet Innsbruck
Universitätsklinik für Innere Medizin V Innsbruck
Innsbruck, Austria
Stadt Wien Wiener Gesundheitsverbund
Klinik Floridsdorf Abteilung für Innere Medizin und Pneumologie
Langenzersdorf, Austria
UZ Leuven
Pneumology
Heverlee, Belgium

Sponsor: Nuvalent Inc.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.