ALK Positive Non-Small Cell Lung Cancer: Chemotherapy Plus Lorlatinib

We are studying a combination of chemotherapy and Lorlatinib for patients with ALK positive NSCLC who have had disease progression outside the brain. The goal is to see if this treatment improves outcomes compared to past therapies.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carboplatino Hikma
Carboplatino Hikma is a chemotherapy medicine used to treat various types of cancer.
Cisplatino Accord Healthcare Italia
Cisplatino Accord Healthcare Italia is a chemotherapy medicine used to treat various types of cancer.
Lorviqua

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.
Cisplatin
Cisplatin is a substance used in chemotherapy to kill or stop the growth of cancer cells.
Lorlatinib
Lorlatinib is a targeted treatment that blocks ALK and ROS1 proteins to treat certain types of lung cancer.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alimta
Alimta
Armisarte

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centro Di Riferimento Oncologico Di Aviano
Oncologia Medica e dei Tumori Immuno-correlati
Aviano-Castello, Italy
Careggi University Hospital
SODc Oncologia Medica e Clinica
Florence, Italy
Azienda Unita' Sanitaria Locale Toscana Nord Ovest
UOC Oncologia Medica
Livorno, Italy

Sponsor: Centro Di Riferimento Oncologico Di Aviano
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.