Allopurinol for Brain Protection in Newborns with Heart Disease

We are studying whether allopurinol can help reduce brain injury in newborns with critical congenital heart disease during and after cardiac surgery. This trial will also assess its effects on brain and heart function, as well as overall development.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Acepurin

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Allopurinol (Ph. Eur.)
Allopurinol is a substance that lowers uric acid levels and helps prevent gout attacks and related complications.
Allopurinol Sodium
Allopurinol sodium is a substance that lowers uric acid levels to prevent gout attacks and uric acid kidney stones.
Mannitol
Mannitol is a substance that helps draw excess fluid out of tissues to reduce swelling and lower pressure in the brain or eyes.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adnamil
Allobeta
Allonol

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Universitair Medisch Centrum Utrecht
Neonatology
De Bilt, Netherlands
Universitair Medisch Centrum Groningen
Neonatology
Groningen, Netherlands
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Neonatology
Rotterdam, Netherlands
Sponsor: Universitair Medisch Centrum Utrecht
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.