ALS Treatment: EH-301 and N-Acetylcysteine with Riluzole

We are studying a new combination therapy for people with ALS to see if it can slow disease progression and improve muscle strength and quality of life. This trial compares the treatment to a placebo to evaluate its effectiveness.

1-2 years 11-15 visits Safety phase (I)Efficacy phase (II)Post-Trial Drug Access Investigational Medicines OralNeurology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Riluzole Eg

Riluzole Eg is a medicine used to slow the progression of ALS, a disease that causes gradual muscle weakness.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Acetylcysteine

Acetylcysteine helps thin and loosen mucus to clear airways in respiratory conditions and treats acetaminophen (paracetamol) overdose.

Riluzole

Riluzole is a substance used to treat amyotrophic lateral sclerosis (ALS) that may slow nerve damage and modestly extend survival.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Bicarbonato Sódico

Ácido Cítrico

Maltodextrina

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alsemol

Emylif

Glentek

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Hospital Universitario Donostia

Neurology

Donostia / San Sebastián, Spain

Sponsor: Asociacion Instituto Biogipuzkoa

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.