Anemia in Low-Risk Myelodysplastic Syndrome: Luspatercept vs Epoetin Alfa

We are comparing a new treatment, luspatercept, with a standard treatment, epoetin alfa, for patients with low-risk myelodysplastic syndrome who do not need blood transfusions. The goal is to see which treatment better helps manage anemia.

>2 years Confirmation phase (III)Post-Trial Drug Access No Placebo Partially Remote Standard Medicines InjectionHematologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Binocrit

Binocrit is a medicine used to treat anemia by helping the body make more red blood cells.

Epoetin Alfa Hexal

Epoetin Alfa Hexal is a medicine that helps raise red blood cell levels to treat anemia from kidney disease or chemotherapy.

Reblozyl

Reblozyl is a medicine for adults that helps treat severe anemia caused by beta-thalassemia or certain bone marrow disorders.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Epoetin Alfa

Epoetin alfa is a substance that stimulates the body to produce red blood cells to treat anemia.

Luspatercept

Luspatercept is a substance that helps increase red blood cell production to treat certain types of anemia and reduce the need for transfusions.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abseamed

Eprex

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fakultni Nemocnice Brno

Interni hematologicka a onkologicka klinika FN Brno

Brno, Czechia

Fakultni Nemocnice Ostrava

Klinika hematoonkologie

Hlučín, Czechia

Vseobecna Fakultni Nemocnice V Praze

I. interni klinika - klinika hematologie 1.LF a VFN

Prague, Czechia

Sponsor: Celgene Corp.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.