Anesthesia in Young Children: Low-Dose vs. Standard Sevoflurane

We are comparing the effects of low-dose sevoflurane combined with dexmedetomidine and remifentanil against standard sevoflurane anesthesia on cognitive development in children under 2 years old. The goal is to see which method supports better brain development as they grow.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dexmedetomidine Hydrochloride
Dexmedetomidine hydrochloride is a substance that provides calming sedation to help patients stay relaxed and lightly sedated during procedures or intensive care.
Sevoflurane
Sevoflurane is a substance used to induce and maintain unconsciousness during surgical procedures via inhalation.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliero-Universitaria Ss Antonio E Biagio E Cesare Arrigo
SC Anestesia Pediatrica Presidio Ospedale Infantile C.Arrigo
Alessandria, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
Anestesia e rianimazione pediatrica
Bologna, Italy
Azienda Ospedaliera Universitaria Meyer IRCCS
S.S. Anestesia
Florence, Italy

Sponsor: Giannina Gaslini Institute For Scientific Hospitalization And Care
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.