Anti-CD19 CAR T-Cell Therapy for Autoimmune Diseases

We are studying a new treatment for people with active B-driven autoimmune diseases like lupus and scleroderma. The trial aims to evaluate its safety and initial effectiveness in managing these conditions.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Levetiracetam
Levetiracetam is a medicine that helps prevent and control seizures in people with epilepsy.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cyclophosphamide
Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.
Fludarabine Phosphate
Fludarabine phosphate is used to treat certain blood cancers, especially chronic lymphocytic leukemia and some lymphomas.
Levetiracetam
Levetiracetam is a substance that helps prevent or reduce seizures in people with epilepsy.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Cd19-Car Lenti

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Cezarius
Cinaz
Desitrend

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dipartimento di scienze dell'Invecchiamento, Ortopediche e Reumatologiche
La Massimina-Casal Lumbroso, Italy
Ospedale Pediatrico Bambino Gesu'
Area Studi Clinici Oncoematologici e Terapie Cellulari
Rome, Italy
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.