Aortic Stenosis: Protamine for Heart Procedure Safety

We are studying whether using protamine sulfate can reduce complications like strokes and bleeding during heart valve surgery. This trial is for patients with aortic stenosis undergoing transcatheter aortic valve implantation.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Protamine Choay
Protamine Choay is a medicine used to reverse the effects of certain blood thinners given during surgery.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Protamine Sulfate
Protamine sulfate is a substance that reverses the blood-thinning effects of heparin after surgery or overdose.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Prosulf
Protamin
Protamin Me

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire De Caen Normandie
Cardiology
Caen, France
Centre Hospitalier Universitaire De Bordeaux
Medical surgical unit for valvular disease
Canéjan, France
Assistance Publique Hopitaux De Paris
Cardiology
Issy-les-Moulineaux, France

Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.