Atopic Dermatitis: Methotrexate Injection Study

We are testing whether subcutaneous methotrexate can improve skin symptoms in adults with moderate to severe atopic dermatitis compared to a placebo. The study also examines safety and quality of life for participants.

3-6 months 6-10 visits Confirmation phase (III)Standard Medicines Oral InjectionAllergologyDermatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Acidum Folicum Léčiva

Acidum Folicum Léčiva is a vitamin medicine used to prevent and treat folate deficiency and help reduce risk of birth defects in pregnancy.

Desoximetason Bipharma

Desoximetason Bipharma is a topical steroid cream used to reduce inflammation and itching from eczema, dermatitis, and other inflammatory skin conditions.

Tacrolimus

Tacrolimus is a medicine that suppresses the immune system to help prevent organ transplant rejection and to treat severe eczema.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Desoximetasone

Desoximetasone is a topical corticosteroid substance that reduces inflammation and itching in inflammatory skin conditions like eczema and dermatitis.

Folic Acid

Folic acid is a B vitamin that helps make healthy red blood cells and prevent birth defects when taken during pregnancy.

Methotrexate

Methotrexate is a substance that slows rapid cell growth and calms the immune system to treat certain cancers and autoimmune conditions.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acfol

Acide Folique Arrow

Acide Folique Biogaran

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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CCR Ostrava s.r.o.

Ostrava, Czechia

Pratia Pardubice a.s.

Pardubice, Czechia

Clintrial s.r.o.

Prague, Czechia

Sponsor: Medac Gesellschaft fuer klinische Spezialprapaerate mbH

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.