Atypical Teratoid/Rhabdoid Tumors: High-Dose Chemotherapy vs. Radiotherapy

We are studying whether high-dose chemotherapy is as effective as radiotherapy for young children with ATRT. This trial aims to improve treatment options and understand the long-term effects on health and quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Holoxan
Lyovac-Cosmegen
Lyovac-Cosmegen is a chemotherapy medicine used to treat certain types of cancer.
Tepadina
Tepadina is a chemotherapy medicine used to treat certain cancers and to prepare patients for bone marrow (stem cell) transplants.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.
Cyclophosphamide
Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.
Dactinomycin
Dactinomycin is a substance used to treat various cancers by blocking cancer cells’ ability to grow and divide.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Cyclophosphamide
Doxorubicin

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Cosmegen
Ifo-Cell
Ifo-Cell N 1000

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven
Pediatric hemato-oncology
Heverlee, Belgium
Association Hospitaliere De Bruxelles Hopital Universitaire Des Enfants Reine Fabiola
Pediatric hemato-oncology
Jette, Belgium
Universitair Ziekenhuis Gent
Pediatric Hemato-oncology and stem cell transplantation
Ledeberg, Belgium

Sponsor: GPOH gGmbH
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.