B-Cell Acute Lymphoblastic Leukemia: Inotuzumab Ozogamicin Study

We are examining whether Inotuzumab can help adults with B-Cell Acute Lymphoblastic Leukemia achieve MRD negativity before stem cell transplantation. The study will also look at treatment safety and survival rates.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Besponsa
Besponsa is a medicine used to treat certain relapsed or hard‑to‑treat acute lymphoblastic leukemia, a type of blood cancer.
Prednisone Eg
Prednisone Eg is a steroid medicine that reduces inflammation and treats allergic, autoimmune, and other inflammatory conditions.
Purinethol
Purinethol is a chemotherapy medicine used to treat certain blood cancers, especially leukemia.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cyclophosphamide
Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.
Inotuzumab Ozogamicin
Inotuzumab ozogamicin is a targeted antibody-based therapy that binds B-cell leukemia cells to deliver a toxin and kill cancer cells.
Mercaptopurine
Mercaptopurine is an anticancer substance used to slow the growth of cancer cells, commonly for treating certain types of leukemia.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Brucorten
Cison
Cortancyl

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliero-Universitaria Ss.Antonio E Biagio E C.Arrigo Alessandria
DIPARTIMENTO INTERNISTICO E DI EMERGENZA-URGENZA E ACCETTAZIONE STRUTTURALE
Alessandria, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I G M Lancisi G Salesi
DIPARTIMENTO DI MEDICINA INTERNA
Ancona, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
DIPARTIMENTO AREA MEDICA ED ONCOLOGIA
Beinasco, Italy

Sponsor: Fondazione Gimema Franco Mandelli Onlus
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.