BCG Vaccine for Radiologically Isolated Syndrome (RIS)

We are studying whether the BCG vaccine can help reduce new brain lesions in people diagnosed with Radiologically Isolated Syndrome. The trial also looks at the safety of the vaccine and other brain changes over time.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bcg 10 Anti-Tuberculosis Vaccine
Bcg 10 Anti-Tuberculosis Vaccine is used to help prevent tuberculosis, a serious infection that mainly affects the lungs.
Bcg Vaccine Ajv
Bcg Vaccine Ajv is a vaccine used to help prevent severe forms of tuberculosis, especially in infants and young children.
Sodio Cloruro S.A.L.F
Sodio Cloruro S.A.L.F is a saline (salt water) solution used to hydrate patients and clean or rinse wounds and medical equipment.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bacillus Calmette-Guérin (Bcg)
Bacillus Calmette-Guérin (BCG) is a vaccine that helps protect against severe forms of tuberculosis, especially in young children.
Brasilian Moreau Substrain
Brasilian Moreau Substrain is a vaccine substance used to help prevent tuberculosis.
Danish Strain 1331

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Addex Natriumklorid
Aminoplasmal E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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University Of Bari Aldo Moro
AOU Consorziale Policlinico di Bari -UOC di Neurofisiopatologia
Altamura, Italy
Azienda Socio Sanitaria Territoriale Della Valle Olona
PO Gallarate - Centro Studi Sclerosi Multipla - Neurologia 2 - Recupero Neurologico
Busto Arsizio, Italy
Azienda Socio Sanitaria Locale N. 8 Di Cagliari
Ospedale “R. Binaghi" - Centro Sclerosi Multipla
Cagliari, Italy

Sponsor: Fondazione Italiana Sclerosi Multipla Ente Del Terzo Settore/et S
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.