BCR-ABL1+ Chronic Myeloid Leukemia: Asciminib Treatment Study

We are studying Asciminib, alone or with Nilotinib, for adults with BCR-ABL1+ Chronic Myeloid Leukemia. The goal is to see if this treatment helps achieve better disease control and improves quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Nilotinib
Nilotinib is a medicine used to treat a type of blood cancer called chronic myeloid leukemia.
Scemblix
Scemblix is a medicine used to treat a type of blood cancer called chronic myeloid leukemia.
Tasigna
Tasigna is a medicine used to treat a specific type of chronic myeloid leukemia, a form of blood cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Asciminib Hydrochloride
Asciminib hydrochloride is a substance that helps control chronic myeloid leukemia by blocking the cancer-causing BCR-ABL protein.
Nilotinib
Nilotinib is a substance that blocks cancer cell growth by targeting specific enzymes and is used to treat chronic myeloid leukemia.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Krufton
Krufton
Lobynia

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliero Universitaria Delle Marche
MEDICINA INTERNA-SOD CLINICA DI EMATOLOGIA
Ancona, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
DIPARTIMENTO MALATTIE ONCOLOGICHE ED EMATOLOGICHE
Bologna, Italy
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
EMATOLOGIA
Brescia, Italy

Sponsor: Fondazione Gimema Franco Mandelli Onlus
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.