Bipolar Depression: Esketamine Nasal Spray

We are studying the safety and effectiveness of esketamine nasal spray for people with treatment-resistant bipolar depression. This trial aims to gather important information that could lead to future studies.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Esketamine
Esketamine is a fast-acting antidepressant substance used to relieve depression symptoms when other treatments haven't worked.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Spravato

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Academisch Ziekenhuis Leiden
Psychiatry
Leiden, Netherlands
Sponsor: Academisch Ziekenhuis Leiden
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.