Bipolar Depression: New Treatment Approach

We are investigating whether a six-week intensified medication plan helps people with bipolar depression who didn't respond to their first treatment. We’ll compare this new approach to standard care to see which is more effective.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bupropion
Bupropion is a medicine used to treat depression and help people stop smoking.
Escitalopram
Escitalopram is a medicine used to treat depression and certain anxiety disorders.
Quetiapine
Quetiapine is a medicine used to treat schizophrenia and bipolar disorder by helping control mood swings and symptoms like hallucinations.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bupropion
Bupropion is a substance that helps lift mood and reduce nicotine cravings for depression and smoking cessation.
Bupropion Hydrochloride
Bupropion hydrochloride is a substance that treats depression and helps people quit smoking.
Citalopram
Citalopram is a substance that helps improve mood and reduce symptoms of depression and anxiety.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Lithium

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aciprex
Adjuvin
Aflizan

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Innsbruck
Universitätsklinik für Psychiatrie I (University Clinic for Psychiatry I)
Innsbruck, Austria
Universitätsklinik für Psychiatrie und Psychotherapie Bielefeld
Psychiatrie und Psychotherapy
Bielefeld, Germany
University Hospital Frankfurt am Main
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy
Frankfurt am Main, Germany

Sponsor: Universitair Medisch Centrum Utrecht
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.